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Loneliness Linked To Higher Type 2 Diabetes Risk

Loneliness imparts a higher risk of death at a level similar to factors like smoking and alcohol consumption. New research suggests that loneliness may also play a role in developing type 2 diabetes. Published in the journal Diabetologia, a new study from researchers at Kings College London found that those who were lonely were more likely to develop type 2 diabetes over the next 13 years.


Diabetes has become one of the top 10 causes of death around the world, according to the World Health Organization (WHO), with the number of people diagnosed with the disease increasing significantly over the past 20 years. The WHO reported a 70 per cent increase since 2000, and said the disease was also behind the largest rise in male deaths among the top 10 global health-related causes of death. The latest peer-reviewed study, published in Diabetologia, the journal of the European Association for the Study of Diabetes, builds on recent research that suggests feelings of loneliness and psychological stress may be a risk factor for Type 2 diabetes. It is one of the first population-based studies to analyse this association, however.


While researchers are still trying to fully understand the connection between stress and Type 2 diabetes, it is believed that high levels of cortisol, a stress hormone, could result in temporary insulin resistance. This in turn can affect how the brain regulates eating behaviours, such as craving more carbohydrates, which can elevate blood sugar levels.Researchers with Western Norway University of Applied Sciences examined that association and whether it could also be the result of depression and insomnia, as both have been linked to loneliness and diabetes.


Data collected from the HUNT study, a collaboration between the Norwegian University of Science and Technology’s HUNT Research Centre and several Norwegian health organizations and authorities, was used by researchers for analysis. The HUNT study collected information from self-reported questionnaires, medical examinations, and blood samples in four population surveys conducted between 1984 and 2019 from more than 230,000 people. Researchers focused on data collected from 24,024 individuals between 1995 to 1997 as the baseline and whether these individuals eventually developed Type 2 diabetes over the course of more than two decades.


The scientists found that those who expressed feelings of loneliness in the 1995 to 1997 baseline “were strongly associated with a higher risk of Type 2 diabetes as measured 20 years later,” according to the paper. The study found that 4.9 per cent of the people in the group, or 1,179, developed Type 2 diabetes. Nearly 13 per cent of participants in the study said they experienced feelings of varying degrees of loneliness. Results also showed that men were more likely to develop Type 2 diabetes at 59.3 per cent compared to 44 per cent of women, and were older at 47.9 years of age. Those with Type 2 diabetes were also more likely to be married, at 73.1 per cent, compared to 67.5 per cent, and had the least amount of education, at 34.8 per cent compared with 23.3 per cent.


“We also found a statistically significant, but weak, mediating effect of sleep maintenance insomnia. However, the results did not support our hypotheses that the association between loneliness and Type 2 diabetes is mediated by sleep-onset insomnia, terminal insomnia or symptoms of depression,” the authors wrote. “After adjusting for age, sex and education level, we found that participants who responded ‘very much’ to the question on experiencing loneliness had two times higher odds of Type 2 diabetes 20 years later than those who had not felt lonely.”


The latest research supports findings from two recent prospective studies that examined loneliness and Type 2 diabetes risk and found loneliness to be a “significant predictor” of the disease after adjusting for various factors, such as sex, age, education, alcohol consumption, physical activity, and body mass index. Researchers did express some caution when interpreting their results, even though they were in line with earlier studies. Some follow-up data from the last population survey conducted between 2017 to 2019 were incomplete and a large number of participants from the most recent survey were also excluded due to missing information on blood test outcomes. The authors noted that both factors were potential sources of bias and could impact results.


In addition, Type 2 diabetes was based on hemoglobin A1c diagnostic tests that measure the amount of blood sugar bonded to the hemoglobin, which means those taking medication to regulate their diabetes may have been classified as not having the disease. Finally, many of the variables were based on self-reported questionnaires, raising the possibility that some participants could have given inaccurate answers.


While it was not part of the study, the authors noted that friends and family can have a supportive and positive influence on an individual’s health, including diet, physical activity, and overall stress, and those who are lonely may be more vulnerable to habits and behaviours that put them at greater risk of developing diabetes. “It is important that health-care providers are open to dialogue about an individual’s concerns during clinical consultations, including with regard to loneliness and social interaction,” the authors concluded.


It’s not clear from the study whether managing stress or making an effort to make more friends or to create a more active social life might reduce the risk of developing type 2 diabetes, says Sabine Rohrmann, PhD, MPH, of the Epidemiology, Biostatistics, and Prevention Institute at the University of Zurich in Switzerland. Because loneliness can be subjective, more friends or social contacts don’t necessarily mean people will feel less lonely, says Dr. Rohrmann, who wasn’t involved in the study. Some people who push outside their comfort zone to socialize more may also feel stress as a result that triggers a surge in the cortisol and inflammation that contribute to the development of type 2 diabetes, Rohrmann adds.


This means people who worry about loneliness leading to type 2 diabetes may want to focus their prevention efforts on things that don’t cause stress for them, like eating healthier foods or exercising more. “A walk in the park — even by oneself — is a good start,” Rohrmann suggests.